Cancer stage, chemotherapy treatment, hormonal treatment, menopause status, physical activity and smoking history increase risk of bone fracture for cancer survivors.
Adult cancer survivors, specifically those who have received chemotherapy, hormonal blockade therapy and/or a diagnosis within five years, are at an increased risk for bone fractures.
Recent studies published JAMA Oncology, also demonstrated decreased risk for physically active survivors and increased risk for smokers.
“These findings are important as the number of cancer survivors living in the United States is projected to rise to 26.1 million by 2040. Research like this seeks ways for cancer survivors to have a better quality of life after their diagnosis,” said Dr. Erika Rees-Punia, senior principal scientist, behavioral and epidemiology research at the American Cancer Society and lead author of the study, in a press release. “Fractures of the pelvis and vertebrae are more than just broken bones – they are serious and costly.”
Rees-Punia, et al analyzed the association between cancer stage and time of diagnosis with risk of pelvic, radial and vertebral fractures compared to adults without a history of cancer including behavior, lifestyle and type of cancer treatment.
Among 92,431 participants included in the study, 12,943 experienced a frailty-bone fracture. Cancer survivors who were diagnosed with an advanced cancer stage within five years were at the highest risk for bone fractures compared to those without a history of cancer. Osteoporotic fractures occurred in vertebrae, pelvis and hip.
Additionally, cancer survivors who received chemotherapy had a higher rate of fracture, compared to those who did not receive chemotherapy.
“We hope our findings will inform clinical guidance on fracture prevention, which could incorporate physical activity with exercise cancer professionals and smoking cessation programs, to improve quality of life after a cancer diagnosis,” Rees-Punia added.
Additional risks related to loss of bone density include malnutrition, persistent stress and elevated cortisol, use of steroid hormones, hyperthyroidism, estrogen and androgen hormone blockade therapies, oophorectomy, menopause, extended convalescence.
While clinicians primarily focus on risk of osteoporosis and bone fracture in women, men can also develop fracture risk and loss of bone mass. Men with low testosterone and androgens as well as men with prostate cancer being treated with androgen deprivation therapy should also be monitored for fracture risk and bone health.
Recommended Patient Guidance and Screening to reduce risk of bone fracture include
- Bone Mineral Supplements Daily. (Copper free and including bone minerals and co factors)
- Adequate intake of protein daily
- Regular weight bearing and resistance exercise
- Active vs. Sedentary Lifestyle Support
- Stop Smoking Support
- Appropriate Bone Density Scans (DEXA)
- Appropriate N-Telopeptide Crosslinks Urine Tests to assess rate of turnover of bone minerals
- Consultation with physician to determine if anti-resorptive or hormonal medication may be of benefit to manage bone density and fracture risk
Selected References
Rees-Punia E, Newton CC, Parsons HM, et al. Fracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer. JAMA Oncol. Published online November 03, 2022. doi:10.1001/jamaoncol.2022.5153
Suarez-Almazor ME, Pundole X, Cabanillas G, Lei X, Zhao H, Elting LS, Lopez-Olivo MA, Giordano SH.
JAMA Netw Open. 2022 Apr 1;5(4):e225432. doi: 10.1001/jamanetworkopen.2022.5432.
PMID: 35363269
Daya NR, Fretz A, Martin SS, et al. Association Between Subclinical Thyroid Dysfunction and Fracture Risk. JAMA Netw Open. 2022;5(11):e2240823. doi:10.1001/jamanetworkopen.2022.40823
Bauer DC. Clinical Use of Bone Turnover Markers. JAMA. 2019;322(6):569–570. doi:10.1001/jama.2019.9372
эротический видеочат онлайн. Click Here: http://rt.livepornosexchat.com/
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
melbet промокод. Click Here: https://bit.ly/3YSgux0
how to get plaquenil cheap [url=https://plaquenil.shop/]generic plaquenil online pharmacy[/url] plaquenil medicine price in india
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
acheter plaquenil sans ordonnance [url=https://plaquenil.xyz/]plaquenil prix le moins cher[/url] plaquenil generique meilleur prix
plaquenil mexique [url=https://plaquenil.store/]medicament hydroxychloroquine[/url] commander plaquenil usa
sovaldi in pakistan ferozsons [url=https://sofosbuvir.online/]sovaldi reviews[/url] sovaldi sofosbuvir tablets
Waiting patiently for you to come home and fuck me! https://bit.ly/3UKFVxa
daklinza price in europe [url=https://daclatasvir.online/]sofosbuvir daclatasvir price[/url] daklinza ndc
seroquel 300 mg price australia [url=https://seroquela.shop/]buy seroquel online cheap[/url] seroquel generic price
Code Promo 1xBet. Click Here: https://popvalais.ch/wp-includes/inc/?code-promo-1xbet-burkina-faso-78-000xof.html
quetiapine price [url=https://quetiapine.space/]quetiapine 325 mg[/url] quetiapine pills 300 mg
quetiapine online prescription [url=http://quetiapine.site/]can i buy quetiapine online[/url] quetiapine medication price
http://seroquelhelp.shop/ [url=http://seroquelhelp.shop/]seroquel 300 mg price australia[/url] cost of generic seroquel
quetiapine uk [url=https://quetiapineden.com/]quetiapine 50 mg[/url] quetiapine 50 mg price in india
quetiapine 125 mg [url=http://quetiapine.store/]quetiapine cost australia[/url] how to buy quetiapine online
quetiapine mexico pharmacy [url=http://quetiapine.shop/]quetiapine online prescription[/url] quetiapine
seroquel 300 [url=http://seroquelola.shop/]seroquel tablets for sale[/url] seroquel 100 mg coupon
seroquel australia [url=http://seroquelb.com/]seroquel canada[/url] 900 mg seroquel
lyrica narcotic [url=https://lyrica.gay/]who makes lyrica[/url] lyrica generic 2018
generic lyrica 150mg [url=http://lyrica.one/]buy lyrica 150mg online[/url] buy pregabalin for sale
pregabalin us [url=http://lyrica.cloud/]buy lyrica 150mg online[/url] order lyrica 150mg sale
can you buy viagra at the store s gone out every fifth day on his turn and hasnГў
kamagra jelly During a female s lifetime, only 400 to 500 eggs are released during ovulation
clomid bData missing for 27 cases and 10 controls
generic cialis online europe MicroRNA biology illustrates the extensive involvement and functional consequences of cross talk between tumor cells and CAFs the effects are reciprocal
Statistical analysis was made by LS and SG safe place to buy zithromax Orotic acid acts as a transporter that carries magnesium into the cells
Промокод 1xbet. Click Here: http://www.newlcn.com/pages/news/promo_kod_1xbet_na_segodnya_pri_registracii.html
Next generation targeted sequencing for CTC, WES for tissue biopsy, and ddPCR for cfDNA identified high confidence mutations top half of each patient table and CNAs bottom half in patient 2 A and patients 4 30 B priligy medicine
buy clomid for men online A very large fertility patient satisfaction survey in the UK revealed that most women felt that their emotional needs were overlooked Souter et al
bpm beats per min female viagra drops
Therefore, it is interesting that of the five tamoxifen metabolites examined, only the serum concentrations of 4OHNDtam was positively associated with the serum levels of FSH in this situation of steady state tamoxifen kinetics clomid fertility drugs