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Brain Cancer-related cognitive impairment is attributed to both cancer as well as treatment-related changes in cytokine profiles, blood brain barrier permeability, genetic susceptibility, hormonal factors and mitochondrial dysfunction.
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Eight Nutraceuticals and Phytochemicals that Promote Neuron Repair and Support Restoration of the Blood Brain Barrier and Cognitive Function
1. Melatonin (10-20mg hs) - Maintains Blood Brain Barrier Integrity and Permeability
- Inhibits Matrix Metalloproteinase-9 (MMP-9)
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2. Astragalus (1-6g/day) - Decreases Blood Brain Barrier Permeability
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3. Resveratrol (1000mg bid x 52 weeks) - Regulates Neuro-Inflammation
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- More lipophilic than Resveratrol
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- Shift away from macrophage-produced cytokines to T-lymphocyte-produced cytokines
- Reduction in circulating lipopolysaccharide endotoxins
- Marked reduction in transcription of hippocampal genes related to HPA regulation
6. Curcumin (3-6g/day) - Improves Cognitive Function
- Crosses Blood Brain Barrier
- Supports Axonal Regeneration
- Increases Brain Derived Neurotrophic Factor
- Reduces NeuroInflammation linked to mood dysregulation and cognitive function
- Stimulates Clearance of beta amyloid plaques
7. Omega-3 Fatty Acids (1.8g/d) - Protects Neurons From Toxic Effects of Chemotherapy
- Opposing actions of omega-3 fatty acids and added sugars on cognitive function, neuroinflammation, and adult hippocampal neurogenesis
- A diet rich in long-chain, marine-derived omega-3 fatty acids and low in added sugars may be an ideal pattern for preventing or alleviating neuroinflammation and oxidative stress
8. Lion's Mane Mushroom (3-5g/d) - Enhances Cognition
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- Stimulates the synthesis of Nerve Growth Factor Promotes and Accelerate Myelination
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