Increasing serum levels of phytochemical DIM may be chemopreventive and chemoprotective for prostate cancer.
Cruciferous Cabbage Family vegetables such as (including cabbage, cauliflower, Brussels sprouts, broccoli, kale, arugula, bok choy and more ) are rich in dietary phytochemicals including Sulforaphane-Glucosinolate family molecules 13C (Indole-3-Carbinol) and it’s major bioactive therapeutic metabolite DIM (3 3’di-indole methane).
Chopping, chewing, massaging and lightly steaming cruciferous vegetables activates the plants own catalyzing myrosinase enzyme and exposing the plant to the acid environment in the stomach leading to further metabolism resulting in bio available and bio active DIM. DIM levels can be measured in the serum.
There are numerous studies on the benefits of dietary consumption of cruciferous vegetables.. A high intake of cruciferous vegetables is associated with reduced risk of several human cancers. There are strong associations between high intake of broccoli and breast cancer and prostate cancer in humans. Human cell studies show inhibition of cell growth of several cancers including breast, prostate, pancreatic, colorectal, lung and head and neck cancers.
DIM and Prostate Cancer
DIM appears to be a potent inhibitor of human androgen hormones which may promote expression of androgen receptors on prostate cancer cells which may lead to carcinogenesis. Increasing serum levels of DIM through diet and supplementation may therefore be chemopreventive for prostate cancer.
Human and Cell Studies have shown that increased serum levels of DIM
- Reduces Serum Prostate Specific Antigen
- Reduces Serum Androgen Hormones
- Down Regulates Prostate Stem Cell Activity
- Decreases Nuclear Androgen Receptors
- Induces p450 metabolic detoxification enzymes CYP1A1, CYP1A2 and CYP1B
- Decreases oxidative stress via nrf2-KEAP pathway
The OutSmart Cancer® System is focused upon transforming the tumor microenvironment which is a signaling environment, so that there is less physiologic support for the development and spread of cancer. In a health model (rather than a disease model) we endeavor to transform the biosystem and reduce pro-carcinogenic and proliferative signaling and prevent cellular, nuclear and mitochondrial damage.
Therefore we use phytochemicals such as I3C and DIM and dietary interventions to influence carcinogenic and proliferative signaling in the tumor microenvironment.
Guidelines for Increasing Serum DIM levels
*Amare DE. Anti-Cancer and Other Biological Effects of a Dietary Compound 3,3ʹ-Diindolylmethane Supplementation: A Systematic Review of Human Clinical Trials. Nutrition and Dietary Supplements. 2020;12:123-137
Additional Selected References
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- Bjeldanes LF, Kim JY, Grose KR, et al. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A. 1991;88(21):9543–9547. doi:10.1073/pnas.88.21.9543
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- Ahmad A, Ali S, Wang Z, et al. 3, 3′‐diindolylmethane enhances taxotere‐induced growth inhibition of breast cancer cells through downregulation of FoxM1. Int J Cancer. 2011;129(7):1781–1791. doi:10.1002/ijc.25839
- Ali S, Banerjee S, Ahmad A, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3ʹ-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2008;7(6):1708–1719. doi:10.1158/1535-7163.MCT-08-0354
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- Giovannucci E, Rimm EB, Liu Y, et al. A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol Prev Biomarkers. 2003;12(12):1403–1409.
- Kong D, Heath E, Chen W, et al. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One. 2012;7(3):e33729. doi:10.1371/journal.pone.0033729
- Abdelbaqi K,Lack N, Guns ET, et al. Antiandrogenic and growth inhibitory effects of ring‐substituted analogs of 3, 3′‐diindolylmethane (Ring‐DIMs) in hormone‐responsive LNCaP human prostate cancer cells. Prostate. 2011;71(13):1401–1412.
- Bhattacharjee S, Dashwood RH. Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals. Antioxidants. 2020; 9(9):865. https://doi.org/10.3390/antiox9090865
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